Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19Article Published on 2022-09-072022-11-15 Journal: Viruses [Category] SARS, 치료기술, 치료제, [키워드] ACE2 receptor anti-SARS-CoV-2 antibody cellular protease COVID-19 COVID-19 disease disease dominant exonuclease Genetic genetic susceptibility Genotype Haplotype high risk individual Infection lactic acid dehydrogenase LDH Patient patients with COVID-19 polymorphism Polymorphisms Protective risk risk of COVID-19 RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serine TaqMan assays target cells the SARS-CoV-2 TMPRSS2 transmembrane transmembrane serine protease-2 (TMPRSS2). with COVID-19 [DOI] 10.3390/v14091976 PMC 바로가기
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literatureReview article Published on 2022-08-012022-10-05 Journal: Gene [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE addition affecting age article association CCR5 cellular protease Clinical outcome Comorbidities correlation COVID-19 COVID-19 severity Deletion evaluate expression finding Genetic Genetic predisposition genetic risk genetic susceptibility genetics help HLA haplotypes host genetics IFNs IFNλ immune system individual Mortality mutations polymorphism Polymorphisms Proteins reduced retrieved risk risk factor SARS-CoV-2 several gene severity severity of COVID-19 smoking susceptibility systematic review TLR TMPRSS2 TNF Treatment upregulation vaccination Variability with COVID-19 [DOI] 10.1016/j.gene.2022.146674 [Article Type] Review article
Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections세린 프로테아제 억제제는 SARS-CoV-2 감염에 대한 숙주 감수성을 제한합니다Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] A1AT acute respiratory syndrome Administered Affect affecting age Alpha alpha-1-antitrypsin antithrombin III antitrypsin Antiviral antiviral drug antiviral intervention approach asymptomatic infection asymptomatic infections ATIII can be used cellular cellular protease ciliated cleavage club Comorbidities Comorbidity complex coronavirus disease Coronavirus disease 2019 COVID-19 deficiency determinant determinants disease disease severity Donor door expression expression level Factor Genetic Genetic variation Genetic variations goblet cells highlight Host human donors identification identify identity immune response individual Infection inhibitor inhibitors less lung cell mechanism mechanism of action outcome PAI1 Patient patients plasminogen activator inhibitor 1 Potential potential treatments primary cell primary cells reduce reducing regulate restrict risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 susceptibility Serine serine protease serine protease inhibitor serine protease inhibitors serpin serpin. SERPINA1 SERPINE1 SERPINE2 serpins Severe acute respiratory syndrome severe COVID-19 severe infections Sex Single-cell RNA sequencing Spike protein susceptibility susceptible Symptom target cells TMPRSS2 Treatment Usage Variation viral burden viral entry viral spike protein [DOI] 10.1128/mbio.00892-22 PMC 바로가기 [Article Type] Article
Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteasesArticle Published on 2022-06-062022-11-01 Journal: Virus research [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] acute respiratory syndrome Amino acid amino acid substitution Analysis analyzed Antiviral approach binding cathepsin B cell receptor cellular cellular protease cellular proteases cleavage site cleaving coronavirus coronavirus pathogenesis develop domain functional furin furin cleavage site generate Health help Host host cell protease host protease host range incorporation indicated Infection inhibitor insight Interaction involved maturation MD simulation MD simulations molecular molecular docking multi Mutation plasmin polybasic primary determinant protease Protein proteolytic activation Receptor binding S protein S1 and S2 SARS-CoV-2 SARS-CoV-2 spike protein shown spike Spike protein Spread subunits the S protein tissue tropism [DOI] 10.1016/j.virusres.2022.198845 PMC 바로가기 [Article Type] Article
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties특정 플라보노이드와 2019년 신종 코로나바이러스 수용체 결합 도메인의 상호작용 및 세포성 프로테아제 및 이들의 약동학적 특성에 대한 실리코 분석Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] 2019 2019 novel coronavirus 2019-nCoV acute respiratory syndrome coronavirus Analysis binding blood-brain barrier cathepsin B caused cellular protease cellular proteases Compound conducted coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death drug-likeness eukaryotic cells evaluated FIVE flavonoid flavonoids gallate glycoprotein hepatotoxicity hydrogen Hydrogen bond inhibit Interaction interactions microorganism MM/PBSA molecular molecular docking molecular dynamics molecular dynamics. Molecular mechanics nCoV P-glycoprotein pharmacokinetic Protein Proteins RBD Receptor binding domain respiratory SARS-CoV-2 Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein subgroup substrate supported surface area target proteins the receptor-binding domain TMPRSS2 Toxicity transmembrane serine protease transmembrane serine protease 2 Van [DOI] 10.1080/07391102.2020.1840444 PMC 바로가기 [Article Type] Article
Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study돌연변이가 숙주 세포 수용체 ACE2와 인간 SARS-CoV-2의 수용체 결합 도메인의 구조, 기능 및 역학에 미치는 영향: 분자 역학 시뮬레이션 연구Article Published on 2021-11-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] 6M0J ACE2 ACE2-RBD Affect Alanine alanine mutant alanine mutants Analysis angiotensin angiotensin-converting enzyme-II binding binding affinity cellular protease cellular proteases complex complexes conserved coronavirus Critical Directed mutagenesis disease severity drug Effect entry of SARS-CoV-2 enzyme exhibit FIVE flexible host cell host cell receptor human ACE2 human SARS-CoV-2 hydrogen Infection information inhibitor initiate Interface residues intermolecular hydrogen bond MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation molecular interaction motif Mutagenesis mutant Mutation priming Principal component provide RBD RBM recent Receptor binding Receptor binding domain receptor binding motif receptor binding motif. Receptor-binding domain Replication rate residue residues SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Spike protein supported the binding affinity the receptor-binding domain viral spike protein ward wild-type [DOI] 10.1080/07391102.2020.1802348 PMC 바로가기 [Article Type] Article
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potentialSARS-CoV-2 감염 중 단백질 분해를 특성화하여 치료 가능성이 있는 바이러스 절단 부위 및 세포 표적 식별Article Published on 2021-09-212022-09-10 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] Anti-viral Antibody testing Antigen benefit biology of SARS-CoV-2 causative agent cell line cellular cellular protease cleavage cleavage site cleavage sites COVID-19 COVID-19 pandemic death dose-dependent reduction drugs targeting event identify in vitro infections inhibit inhibit SARS-CoV-2 mass spectrometry MYLK Papain pathogen protease Protease activity Proteases Protein proteolysis proteolytic cleavage provide resource responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 replication shown significant increases in siRNA SRC substrate target targets therapeutic potential titres treat tyrosine vaccinate Vaccine Viral viral infection Viral proteins [DOI] 10.1038/s41467-021-25796-w PMC 바로가기 [Article Type] Article
Host Serine Proteases: A Potential Targeted Therapy for COVID-19 and InfluenzaMolecular Biosciences Published on 2021-08-302022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 activated Activation angiotensin-converting enzyme 2 Antiviral bind can be used cathepsin L cellular protease cleaved coronavirus COVID-19 effective vaccine enzyme FIVE furin help host cell host cells host protease host proteases human proteases indicate Influenza outlined pandemic pathway Pathways Potential provided receptor S glycoprotein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-S serine protease the S protein therapeutic agents Therapeutic approach therapeutic option therapeutic strategy therapeutic targets TMPRSS2 viral infection viral mutation viral S protein viral spike virus [DOI] 10.3389/fmolb.2021.725528 PMC 바로가기 [Article Type] Molecular Biosciences
The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severityResearch Article Published on 2021-06-282022-10-29 Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS, [키워드] Alpha Caco-2 Calu-3 Calu-3 cell line Cell cell line cell type cells cellular entry cellular protease Chronic diseases Colon comorbid disease comorbid diseases Comorbidity Control Coronaviruses COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets death decrease described determine diabete diabetic patient disease disease severity down-regulated down-regulation downregulated drastic reduction Endocrine evaluated example expression Factor Features Health implication increase in inhibit inhibiting inhibitor kidney knockdown liver malignancies mechanism New coronavirus number of infected overexpressing overexpression pancreatic islet pandemic patients priming regulated Regulation S protein SARS-CoV-2 SARS-CoV-2 viral infection scRNA-seq data secretory cell serine protease inhibitor serine protease TMPRSS2 severity shown similarity SPINT2 susceptibility tissues TMPRSS2 triggered Tumor Type unique viral entry Viral load virulence virus while [DOI] 10.1371/journal.ppat.1009687 PMC 바로가기 [Article Type] Research Article
In Vitro Models for Studying Entry, Tissue Tropism, and Therapeutic Approaches of Highly Pathogenic CoronavirusesReview Article Published on 2021-06-212022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] binding cell entry cell line cell receptor cellular protease CoV CoVs ENCODE family Coronaviridae Genome host cell in vitro model information inhibiting knowledge membranes methodology Model offer Pathogenesis positive-sense Protein RNA virus RNA viruses structural proteins the S protein the Spike therapeutic approaches therapeutic intervention tropism viral tropism [DOI] 10.1155/2021/8856018 PMC 바로가기 [Article Type] Review Article